lower serum levels of uric acid in uterine fi¬broids and fibro-cystic breast disease patients in dongying city, china

background: increasing serum levels of uric acid (sua) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate sua. estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. the study aimed to explore sua among patients suffering from these diseases to enhance the hypothesis. methods: overall , 1349 female participants were selected into three cases: caseⅰhaving uterine fibroids (n=568), caseⅱ having fibrocycstic breast disease (n=608) and caseⅲ having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. based on health check-up data from 2011 to 2012, in dongying shengli oilfield central hospital, a cross-sectional study was conducted to examine the difference in sua between the case and control. we adjusted covariates by generalized linear regression mode. results: from 19 to 44 yr, sua of caseⅰ to caseⅲ were lower than controls by 8.46 umol/l ( p =0.011), 5.88umol/l ( p =0.014) and 9.39 umol/l ( p =0.059), respectively. from 45-54 yr, no significant differences were between three cases and controls. in caseⅰand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, sua in caseⅰwas lower than the control by 32.02umol/l ( p =0.003). conclusion: participants of uterine fibroids and fibrocystic breast disease had a lower sua except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease sua.